This included PD-L1+ macrophages (CD68 positive, CD16 positive, and PD-L1 positive cells), CD8-expressing macrophages (CD68 positive, CD16 positive, and CD8 positive cells), PD-L1+ tumour cells (PD-L1 positive and SOX10 positive cells), and PD-L1+ cytotoxic T-cells (CD8 positive and PD-L1 positive cells; Figure 10). Here, CD274 is linked to neoplasm.