After cerebral ischemia, serum TNF-α and IL-1β content were increased, which can promote the increase of vascular permeability, induce the expression of various inflammatory mediators, damage the blood–brain barrier function, form cerebral edema, and aggravate stroke injury (Sánchez-Gloria et al., 2021; Chen et al., 2015). Here, IL1B is linked to Cerebral ischemia.