More than half a century of research on Trx and TrxR in the field of cancer biology fortified the hypothesis that the Trx system is of utmost significance in cancer cells’ survival, proliferation, invasion, and metastasis (Gromer et al., 2004; Arner and Holmgren, 2006; Holmgren and Lu, 2010; Jia et al., 2019). Here, TXN is linked to cancer.