TXN and neoplasm: Several processes lead to this adaptation: (I) increased expression of detoxifying antioxidant enzymes, such as Trx (Janssen et al., 1999; Janssen et al., 2000; Arner and Holmgren, 2006; McLoughlin et al., 2019), (II) inactivation of enzymes for H2O2 removal (Toledano et al., 2010), (III) inactivation of tumor suppressors (Leslie et al., 2003), and (IV) increased synthesis of small antioxidant molecules, such as GSH (Traverso et al., 2013).