Increased expression of MnSOD correlates with tumor malignancy (Ria et al., 2001; Nozoe et al., 2003; Landriscina et al., 2009; Fu et al., 2016), while moderately elevated expression of MnSOD significantly increases the probability of survival and developing resistance to drugs (Fu et al., 2016). Here, SOD2 is linked to neoplasm.