ADPRS and neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures: <b>Background:</b> Gene variants of ADP-ribosylserine hydrosylase, also known as ADP-ribosylhydrolase-like 2 (<i>ADPRS</i> or <i>ADPRLH2;</i> OMIM: 610624), can cause stress-induced childhood-onset neurodegeneration with variable ataxia and seizures (CONDSIAS, OMIM: 618170), an ultra-rare neurodegenerative autosomal recessive disorder.