HIF1A and cirrhosis of liver: Compared with normal liver tissue, viral hepatitis, liver cirrhosis, and hepatocellular carcinoma are more obvious; in addition, HIF-1α-induced glucose transporter-1 (G-lut1) and vascular endothelial growth factor (VEGF) gene expressions promote glycolysis and induce angiogenesis, which is closely related to the occurrence, development, and proliferation of cancerous cells of liver cancer [30].