In this research, the expression and correlation of HIF-1α, YAP, and TAZ in normal cervical tissues, CIN and CSCC tissues, and cervical cancer cells were further detected by in vivo and in vitro assays, so as to further explore the roles of the three in the malignant progression of CSCC. This evidence concerns the gene HIF1A and cervical squamous intraepithelial neoplasia.