RB1 and pineoblastoma: The fourth and fifth pineoblastoma subgroups, called PB-MYC/FOXR2 and PB-RB1 are characterized by an oncogenic MYC-miR-17/92-RB1 axis and are generally seen in infants and young children, precluding utilization of radiation-based strategies, and are linked with dismal outcomes with 5-year OS ranging from 0% to 25%.