Several of the SAA1 signal peptides studied come from the amino acid sequence of reptiles and fish where no cases of systemic amyloidosis have been recorded: for example, Sterlet Fish (Acipenser ruthenus) (signal peptide 5) and Chinese Softshell Turtle (Pelodiscus sinensis) (signal peptide 12) [29]. This evidence concerns the gene SAA1 and primary systemic amyloidosis.