NOTCH4 and bipolar disorder: This analysis revealed top genes, such as NOTCH4, MICA, TRIM27, PBX2, and FKBPL, as enriched in GWAS of schizophrenia, CLZ-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia, and bipolar disorder among other psychiatric and non-psychiatric conditions (Supplementary Figure 2).