ALP: alkaline phosphatase; AMA: antimitochondrial autoantibodies; AMA-M2: M2-subtype antimitochondrial autoantibodies; ANA: antinuclear antibodies; anti-La/SSB: autoantibodies directed against anti-La/SSB autoantigens; anti-Ro/SSA: autoantibodies directed against Ro/SSA autoantigens; ESR: erythrocyte sedimentation rate; GGT: gamma-glutamyl transpeptidase; gp210: anti-nuclear glycoprotein 210 autoantigen; PBC: primary biliary cholangitis; pSS: primary Sjögren's syndrome; sp100: anti-nuclear sp100 autoantigen. The gene discussed is TRIM21; the disease is primary biliary cholangitis.