AMA: antimitochondrial autoantibodies; ANA: antinuclear antibodies; anti-La/SSB: autoantibodies directed against anti-La/SSB autoantigens; anti-Ro/SSA: autoantibodies directed against Ro/SSA autoantigens; ESR: erythrocyte sedimentation rate; PBC: primary biliary cholangitis; pSS: primary Sjögren's syndrome. The gene discussed is CALR; the disease is peeling skin syndrome.