In our study, female Balb/c mice were used to establish the neutrophilic asthma model and simultaneously administered with a high selective NLRP3 inhibitor, MCC950, as well as the specific caspase-1 inhibitor Ac-YVAD-cmk for therapeutic purposes, and the relationships among NLRP3/caspase-1/IL-1β pathway, neutrophilic airway inflammation, and Th17/Treg immune responses were determined. This evidence concerns the gene CASP1 and inflammatory response.