Minichromosome maintenance (MCM) proteins are essential for the initiation of DNA replication, and it has been detected to be overexpressed in various cancer tissues, including lung squamous cell carcinoma (Wu et al., 2018), breast cancer (Juríková et al., 2016), glioma (Cai et al., 2018), hepatocellular carcinoma (Liu et al., 2018), etc. As an important player in the initiation pathway of DNA replication, Minichromosome maintenance 10 (MCM10) was first identified in a yeast genetic screen and only presents in eukaryotes (Aves et al., 1998). The gene discussed is MCM10; the disease is central nervous system cancer.