For example, knockdown of MCM2 reduces the expression of cyclinD1, cyclinA and CDK4, knockdown of MCM3 reduces the expression of cyclinA, knockdown of MCM6 causes CyclinA, CyclinB1,CyclinD1, silencing of MCM7 reduces cyclinD1, cyclinE2 and CDK2, and down-regulation of cyclinD1 in breast cancer cells with MCM10 knockdown (Zhang et al., 2015; Qiu et al., 2017; Liu et al., 2018; Yang and Wang, 2019). The gene discussed is CCNA2; the disease is breast cancer.