VHL and hepatocellular carcinoma: Methylation data were available for a total of 52 probes located within the component genes, of which three were hypomethylated in HCC relative to non-malignant liver tissue samples: one within the 5′-UTR of ELOC (cg17316966), and two within the gene body of VHL (cg16869108 and cg20916523) (Supplementary Figure S3).