CRL2pVHL has also been implicated in the degradation-promoting ubiquitination of other substrates, but many of them, including activated epidermal growth factor receptor (EGFR), zinc fingers and homeoboxes 2 (ZHX2), and never-in-mitosis A-related kinase 8 (NEK8), have also been linked to tumour growth or poor patient outcomes (Zhou and Yang, 2011; Ding et al., 2018; Zhang et al., 2018). Here, ZHX2 is linked to neoplasm.