The genes with decreased expression, TFDP1, RBL2, LIN52, and LIN54 in KIRC; TFDP1 in LGG; RBL2 and E2F4 in KICH; RBL2 in ACC; RBBP4, LIN52 and E2F5 in GBM; RBL1 and TFDP2 in READ; and TFDP2 in UVM, were associated with poor survival (p < 0.05, Supplementary Figure S1A). The gene discussed is E2F4; the disease is reading.