Figures 1A and B show the data from TCGA and GEO, respectively. It was found that in adrenocortical carcinoma, breast cancer, bladder cancer, colon cancer, head and neck cancer, kidney cancer, stomach adenocarcinoma, prostate cancer, lung cancer, and COAD, the INSC mRNA expression was lower in tumors than in normal tissues. Figures 1C–F illustrate the mRNA expression of INSC in COAD from TCGA and GEO. INSC expression was considerably lower in COAD tissues than in normal tissues (p < 0.001). This evidence concerns the gene INSC and colonic neoplasm.