Rearrangement of their sub-networks reveals that the ctag1b/a, magec1 and prame clique (Figures 3B, 5) is maximally two degrees apart from ranbp2, tle1, dyrk1a and six1 in the network, thus linking cta1b/a to the oncogenic pathways of six1 (cyclinA1 or transcriptional misregulation in cancer via the Wnt/Hedgehog/Notch-mediated oncogenesis), dyrk1a (cell cycle control at the G1-G1/S phases), tle1 (NFκB-mediated control of gene transcription), and ranbp2 (mitotic cell cycle control and Notch pathways). The gene discussed is SIX1; the disease is cancer.