FHIT and breast cancer: Epigenetic aspects have been studied as important contributors to the risk and prognosis of BC reported in Egypt, including the role of microRNAs in BC tumor tissues, circulating free miRNA, circulating long non-coding RNA (Hafez et al., 2012; Zidan et al., 2018) in addition to DNA methylation status of known susceptibility genes such as FHIT (Zaki et al., 2015).