CKB and Familial prostate cancer: However, public RNA-seq datasets indicate that CKB is downregulated in human solid tumors, and its lower expression is associated with a worse prognosis in cervical, head–neck, colon (Mooney et al., 2011), gastric (Mello et al., 2015), kidney, ovarian, pancreatic and sarcoma prostate cancer patients (Wang et al., 2021).