TP53 and familial pancreatic carcinoma: In the training cohort, a high-risk group with significant enrichment pathways was concentrated on the p53 signaling pathway, cell cycle, glycosphingolipid biosynthesis lacto and neolacto series, pentose phosphate, glycolysis gluconeogenesis, drug metabolism enzymes, pyrimidine metabolism, and pancreatic cancer pathways (Figure 4A).