The expression of PAICS varies among TCGA tumors and is a poor prognosis factor responsible for breast invasive carcinoma, breast invasive carcinoma-LumA, cervical squamous cell carcinoma, endocervical adenocarcinoma, head and neck squamous cell carcinoma, kidney chromophobe, kidney renal papillary cell carcinoma, brain lower grade glioma, liver hepatocellular carcinoma, lung adenocarcinoma, mesothelioma, sarcoma, and thyroid carcinoma (Supplementary Figures S4, S5). This evidence concerns the gene PAICS and invasive breast carcinoma.