In the present study, we investigated the expression of eight lncRNAs in CRC from the GEO database, and the results confirmed that CAPN10-AS1, NIFK-AS1, SNHG7, and ZEB1-AS1 were highly expressed in CRC tissue compared with normal colon tissues, and Lnc00261 was significantly downregulated in CRC tissues. The gene discussed is CAPN10; the disease is colorectal carcinoma.