TNF and cancer: The EMT-like subtypes are widely enriched in some pathways related to carcinogenic factors, such as cell migration, TNFA signaling, angiogenesis, and hypoxia; umbrella subtypes are widely enriched in immune-related pathways, such as immune effector proves, response to cytokine, antigen processing and presentation, and IL2 STAT5 signaling; these factors are all related to cancer suppression.