Patients with retinoblastoma in the high-ICI subgroup highly express late-stage cone markers (e.g. GUCA1A and OPN1SW) (Welby et al., 2017), whereas patients in the low-ICI subgroup highly express proliferation genes (e.g., MKI67 and TOP2A) and retinoblastoma-related genes [e.g., TTK (Zeng et al., 2020) and CDC25A (Singh et al., 2015)], suggesting that immune cell infiltration is associated with retinoblastoma migration and metastatic progression. The gene discussed is OPN1SW; the disease is retinoblastoma.