Multiple evidences illuminated that CMS-induced glucocorticoids overproduction is contributed to stress-related depressive and anxiety-like behaviors 22, 23, thus, chronic corticosterone administration and CMS were performed to model anxiety and depression states, and current results showed that fluoxetine ameliorates CMS/CORT induced nNOS and CAPON expression and coupling. This evidence concerns the gene NOS1 and Anxiety.