To investigate the role of the nNOS-CAPON interaction in 5-HT1AR-mediated anxiety and depressive behaviors, we treated mice with 8-OH-DPAT (0.1 mg/kg/d i.p.)alone or in combination with intrahippocampal DG microinjection of AAV-CAPON-L-GFP for 28 days. The gene discussed is NOS1; the disease is Anxiety.