Consistent with a previous study, we found that CMS exposure increased the expression of both nNOS and CAPON (Figure 1A), enhanced the association of nNOS with CAPON in the hippocampal DG (Figure 1B), and induced mice to display significant anxiety and depressive behaviors determined using the O-maze test (Figure S1A-B), NSFT (Figure S1C-D), OFT (Figure S1G-H), TST (Figure S1E) and FST (Figure S1F). Here, NOS1 is linked to Anxiety.