Given that nNOS-CAPON coupling mediates anxiety behaviors, posttraumatic stress disorder and ischemia-induced impairment of structural plasticity 17, 57, 58, our present study strengthens the observation that nNOS-CAPON coupling, an improved intervention target other than SERT or 5-HT receptors, represents a target for treating neuropsychiatric disorders. The gene discussed is NOS1; the disease is Anxiety.