In addition, disorganized architecture and fibrosis have been found in the muscle of Mecp2 null mice 59; whereas in scleroderma fibroblasts, upregulated Mecp2 inhibits myofibroblast differentiation and fibroblast migration through direct activating the plasminogen activator urokinase, indicating Mecp2 as a negative regulator on fibrosis 60. The gene discussed is MECP2; the disease is scleroderma.