Tumor-infiltrating T-cells enter tumor at an early stage as naïve CD4+ T-cells, followed by macrophage infiltration and contribute to early tumor rejection and/or anti-tumor effects through promoting senescence and tumor apoptosis via secretion of cytokines (such as IFN-γ and TNF) and interact with macrophages, NK cells and CD8+ T-cells to enhance tumor eradication 53. This evidence concerns the gene CD4 and neoplasm.