Although the effect of TRIB1 in TAMs has not been elucidated, previous studies investigated TRIB1 as an oncogene in several contexts 24-26, including prostate and colon cancer and also associated it with sensitivity of breast cancer cells to TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis 27, 59, 60. This evidence concerns the gene TNFSF10 and malignant colon neoplasm.