CD274 and neoplasm: Specifically, TRIB1 expression is associated with lower levels of anti-tumorigenic factors such as IL6 (that promotes hypoxia-induced apoptosis), IL10 and PD-L1 (that regulate T cell immunosuppression), CCL20 (that influences response to chemotherapy) and proangiogenic VEGF. Conversely, higher levels of TRIB1 are linked to increased tumor cell survival (via NOS2) and decreased T cell-mediated immunosuppression (via IL15).