Notably, IL-10 (p < 0.01), PD-L1 (p < 0.0001) and VEGF (p < 0.05) expression were significantly increased in TAMTRIB1-KD compared to MTRIB1-KD (Figure 3J-L), suggesting the myeloid TRIB1 is an important regulator of oncogenic cytokine expression in TAMs, downstream of signals secreted by tumor cells. This evidence concerns the gene CD274 and neoplasm.