TRIB1 and neoplasm: In order to gain an initial mechanistic insight into myeloid TRIB1-dependent alterations, relevant to tumor-biology, we used human monocyte-derived macrophages (MDMs) isolated from healthy human blood and transfected them with TRIB1 siRNA to reduce the expression (MTRIB1-KD) to assess the expression of a range of genes known to play an important role in TAM function.