From those pathways significantly associated with TRIB1 levels in macrophages, such as creation of C4 activators, translocation of ZAP 70 to immunological synapse, PD1 signalling, and phosphorylation of CD3 and zeta chains, have previously all been shown to be involved in the promotion of tumor growth and regulate T-cell activation and polarization 45, 46. This evidence concerns the gene C4A and neoplasm.