Perivascular (PV) TAMs express high levels of MRC1 and VEGF to facilitate tumor angiogenesis, and help formation of paracrine feedback loops (CSF1 from cancer cells, EGF from TAMs, and HGF from endothelial cells) to initiate metastasis and intravasation of cancer cells at the TME of metastasis 50, 51, 66, 67. This evidence concerns the gene EGF and cancer.