We demonstrated that TAM-derived PGE2 stimulated tumor UHRF1 expression (Figure 1) via blocking miR-520d expression (Figure 2), loss of miR-520d expression led HCC progression via tumor UHRF1 (Figure 3), and tumor UHRF1 targeted tumor repressor KLF6 (Figure 4). Here, UHRF1 is linked to hepatocellular carcinoma.