We found that in a cohort of 20 patients with CRC, both the adjacent normal tissues and tumor tissues with high expression of 5-HT2B showed high expression of p21 and that the tissues with low expression of 5-HT2B showed the opposite expression patterns; however, there was no significant correlation between 5-HT2B and cyclin D1 expression (Figures 7C-F and S7C). This evidence concerns the gene CCND1 and neoplasm.