ANXA1 and obesity due to melanocortin 4 receptor deficiency: These microbes, different from those in the ANXA1+/+ sample, are lowered in many diseases, including colorectal cancer, obesity and type 2 diabetes (Table S9). Collectively, these changes in the fecal microbiota revealed that deleting ANXA1 expression attenuated the stress-induced gut microbiome dysbiosis.