Genes in G2 (Tbc1d9) and G3 (Cdh10, Lrrc4c) followed the canonical model (a negative correlation between promotor methylation and gene expression) (R = -1, p = 0.027) (Figure 6B)33, with Tbc1d9 downregulated and Cdh10 upregulated in stress tumors, implying that methylation may play a direct role in the regulation of transcriptomic-level phenotypes in stress-induced tumor development. Here, TBC1D9 is linked to neoplasm.