ANXA1 and metabolic disease: At the phylum level, the F/B ratio in BS ANXA1-/- feces samples was significantly lower than ANXA1+/+ BS feces and did not change upon stress (Figure 7E). The enrichment in gut microbiota functions of metabolism, cell growth and death; metabolic diseases; cancers; and immune system diseases in response to stress in the ANXA1+/+ mice was abolished in the ANXA1-/- mice (Figure 7F).