In contrast, genes in G1 showed a non-canonical and weak correlation pattern (R = 0.44, p = 0.2) (Figure S6A). KEGG pathway analysis demonstrated that G2 and G3 genes are enriched in cancer (Figure 6C). G1 genes were enriched in the MAPK signaling pathway and the oxytocin signaling pathway (Figure S6B). We validated the expression of Cdh10 and Tbc1d9 in breast cancer subsets using the TCGA dataset (http://tcgaportal.org/TCGA/Breast_TCGA_BRCA). The gene discussed is CDH10; the disease is cancer.