Moreover, Faecalibacterium prausnitzii, a member of Clostridium cluster IV, suppressed the proliferation and invasion and promoted the apoptosis of breast cancer cells via inhibition of the secretion of IL-6 and the phosphorylation of JAK2/STAT3 in MCF-7 cells 48, 49. The gene discussed is JAK2; the disease is breast carcinoma.