STAT3 and neoplasm: Gene set variation analysis (GSVA) analysis revealed multiple immune response related pathways, namely IL2-STAT5 signaling, IL6-JAK-STAT3 signaling, allograph rejection, INF-alpha response and INF-gamma response, PI3K-AKT-MTOR signaling, KRAS signaling and glycolysis, were upregulated in tumor samples (Figure 2F).