Ten of the 15 included studies reported the correlation between clinicopathological features and TLSs (TNM stage, 4 studies; age, 5 studies; tumor size, 4 studies; lymph node status, 7 studies; LVI, 4 studies; histological grade, 7 studies; TILs, 3 studies; ER, 3 studies; PR, 3 studies; HER-2, 6 studies; Ki-67, 2 studies). Here, MKI67 is linked to neoplasm.