Moreover, gene expression studies have confirmed that NLRP3 and NLRP1 gene polymorphisms are associated with the development of LN (16, 110, 117) and that the acquired functional variant rs10754558 (NLRP3) is more common in patients with LN, strengthening the view that the NLRP3 inflammasome plays a key role not only in lupus but also in renal damage (16). This evidence concerns the gene NLRP1 and systemic lupus erythematosus.