Clinical studies have shown that expression of the NLRP3/NLRP1 inflammasomes was significantly downregulated in PBMCs obtained from patients with SLE compared with healthy controls; further analysis showed that IFN-I levels were significantly inversely correlated with the expression of NLRP3/NLRP1 inflammasomes, suggesting a negative regulatory effect between IFN-I and the inflammasome in SLE (50). This evidence concerns the gene NLRP1 and systemic lupus erythematosus.