CXCL8 and periodontal disorder: Interleukin-8 (IL-8) is a chemokine that has been linked to periodontal disease. Endothelial cells, gingival fibroblasts, neutrophils, monocytes, and phagocytes in the gingival crevice generate IL-8, a powerful chemoattractant cytokine and neutrophil activator in inflammatory regions.