While the current study found that JP2 is not phagocytized by periodontally healthy neutrophils, previous evidence show that neutrophils do internalize opsonized-JP2 but at greater multiplicity of infection the one used in the current study (50); the current study did not compared phagocytosis in the different periodontal cases which may also be affected by CD18 and result in differences in phagocytosis functionality. Here, ITGB2 is linked to infection.