The only significant differences were between MIPP and healthy control neutrophils in response to JP2: MIPP neutrophils exhibited significantly lower levels of ROS production compared with that of the healthy neutrophils, both as cumulative ROS (as the area under the curve values, AUC) and as endpoint after 90 min bacterial infection (Figure 2B, p<0.001). The gene discussed is MINPP1; the disease is bacterial infectious disease.