Based on the list of differentially expressed genes, 15 differentially expressed IRGs were selected (Figure 2B). The top 5 most enriched KEGG pathways of those 15 IRGs were as follows: PD-L1 expression and PD-1 checkpoint pathway in cancer, NF-kappa B signaling pathway, T-cell receptor signaling pathway, and FoxO signaling pathway (Figure 2C). The gene discussed is CD274; the disease is cancer.