Furthermore, the P2X7 receptor was significantly increased in the plasma of COVID-19 severe patients who had a poor outcome (death or prolonged intensive care unit stay) (Figure 2F) and a multivariate logistic regression analysis showed that an increase in the concentration of soluble P2X7 is associated with severe COVID-19 symptoms (OR = 1.04; [95% CI: 1.013–1.060]; p = 0.002). Here, P2RX7 is linked to COVID-19.