In psoriasis, estrogen might exert its functions by modulating the expression of certain genes like sex-biased transcription co-factor vestigial-like protein 3 (Vgll3) (20) and CCAAT enhancer binding protein beta (cebpb) (21), microRNAs (miR146a, 21 and 210) (22, 23), and chemokines (CCL5 and CXCL10) (24, 25). The gene discussed is CXCL10; the disease is psoriasis.