There were four biological processes involved in oxygen metabolism, and it was hypothesized that puerarin could treat EHF/COVID-19 by influencing these processes.KEGG pathway enrichment analysis of 69 common genes showed that puerarin affects a series of signaling pathways, including coronavirus disease - COVID-19, Th17 cell differentiation, HIF-1 signaling pathway, TNF signaling pathway, Human cytomegalovirus infection, Tuberculosis, Influenza A, Epstein-Barr virus infection Pertussis, Toll-like receptor signaling pathway, and Human immunodeficiency virus 1 infection (Figure 4B). This evidence concerns the gene TNF and COVID-19.