ADA2 (Figure 5B), in most cancers, positively correlated with LGALS9, CD80, CTLA4, LAG3, TNFRSF9, PDCD1LG2, CD274, IDO1, TNFSF14, CD244, CD200R1, CD28, BTLA, PDCD1, CD40LG, ICOS, LAIR1, HAVCR2, CD86, CD48, CD27, and TIGIT. Moreover, ADA2 negatively correlated with CD276, TNFSF9, and VTCN1 in most cancers. The gene discussed is CD28; the disease is cancer.