Donnele Daley and colleagues found that PD-L1 expression switched positive in approximately 50% of γδ T-cells in human and murine pancreatic ductal adenocarcinoma (PDA), and that blocking PD-L1 in γδ T-cells enhanced activation and infiltration of CD4+ and CD8+ T-cells (78). The gene discussed is CD274; the disease is pancreatic ductal adenocarcinoma.