CKS2 and central nervous system cancer: By comparing data from TCGA (including 104 normal brain tissues and 166 high-grade glioma tissues), GSE4290 (including 22 normal brain tissues and 74 glioma tissues), and combined glioma data from TCGA and GTEx, CKS2 was significantly elevated in glioma tissue compared with normal brain tissue (p < 0.001; Figures 1A–C).