Although numerous studies have demonstrated that let-7a does not appear to impact the expression of HMGA2 or RAS family members either in vivo or in vitro, GE11-positive exosomes specifically target EGFR-expressing cancer cells and restrain the growth of HCC70 BRC cells in vivo compared to let-7a-free and GE11-free exosomes (167). The gene discussed is HMGA2; the disease is cancer.