lncFMR1-AS1 can bind to TLR7, activate the TLR7/NF-κB signaling, and elevate c-Myc expression, therefore promoting esophageal squamous cell carcinoma (ESCC) proliferation, anti-apoptosis, and invasive capacity (118). Here, NFKB1 is linked to esophageal squamous cell carcinoma.