TLR4 and Shock: Following hemorrhagic shock, inflammation in WT mice was characterized by 4 principal components involving IL-17A, IL-6, and IL-12p70 among a multitude of other mediators (Figure 3C), while in TLR4-/- mice this response was also characterized by 4 principal components and the mediators IL-12p70, IL-5, and MIP-1α among others (Figure 3D).