Thus, high circulating concentrations of fatty acids can exacerbate CD4+ T cell-mediated pathology via the induction of ORAI1 underscoring that this protein may represent a therapeutic target to attenuate inflammatory diseases that arise from physiological conditions leading to high concentrations of fatty acids in the circulation such as the postpartum period or chronic diseases such as diabetes and obesity. Here, CD4 is linked to obesity due to melanocortin 4 receptor deficiency.