MSCs release the major soluble mediator milk fat globule-EGF factor 8 (MFGE8), which lowers extracellular matrix (ECM) proteins and liver fibrosis in mice by inhibiting transforming growth factor beta 1 (TGFB1)-mediated activation of hepatic stellate cells (HSCs) (10). The gene discussed is TGFB1; the disease is Hepatic fibrosis.