Tissue-resident memory T (TRM) cells are tumor antigen-reactive TILs that produce a magnitude of cytotoxic mediators, such as granzyme B and perforin, as well as cytokines, such as interferon-gamma (IFN-γ) and tumor necrosis factor (TNF), in the tumor microenvironment (TME) (15, 16). This evidence concerns the gene PRF1 and neoplasm.