HMGB1 and telomere syndrome: There were 21 genes (AIFM1, BCL2, BIRC2, CASP6, CHMP4B, FADD, FAS, FASLG, HSP90AA1, IPMK, MAP3K7, PARP1, RIPK1, SPATA2, TNF, TNFAIP3, TNFRSF1A, TNFSF10, TP53, TRAF2 and XIAP) upregulated and 13 genes (CASP8, CFLAR, CYLD, DNM1L, HMGB1, ITPK1, MLKL, PGLYRP1, RIPK3, SQSTM1, TNFRSF10A, TRPM7, and ZBP1) downregulated in STS tumor samples (Figure 2A and Figure S1A).