In summary, we confirmed that ABCs increment their frequency in the circulation of LN patients, and although they cannot be discarded as a factor promoting the pathogenesis of this SLE feature, their numerical alterations could not be as robustly related to LN as those from the non-previously described CD11c+ T-bet+ CD21hi cells that are almost absent when renal manifestations arise. Here, ITGAX is linked to lobular neoplasia.