When we dissected the type of infiltrating macrophage in the colon of DSS-treated mice, we found that Prox1+/– mice showed increased numbers of M2 macrophages close to lymphatics structures (Figures 2A, B, higher magnifications and quantifications), suggesting that this anti-inflammatory macrophage subpopulation could be playing a protective role in the DSS-colitis model. Here, PROX1 is linked to colitis.