Additionally, two literature reviews indicate that the administration of inflammatory cytokines inhibitors, such as tumor necrosis factor-α antagonists and IL-1 inhibitors, reduce depressive symptoms, anxiety, and fatigue, and increase vitality and mental health-related QoL across different patient populations (Raison et al., 2013; Yadlapati and Efthimiou, 2016). The gene discussed is TNF; the disease is Anxiety.