When AAVrh10 containing hFXN expressed under CAG promoter was intraperitonially injected into MCK-Cre mice, it increased frataxin expression in the heart, leading to preservation of the hemodynamic parameters and cardiac output, and also complete reversal of the cardiomyopathy after disease onset (Perdomini et al., 2014). The gene discussed is FXN; the disease is cardiomyopathy.