Growing evidence also demonstrates the role of the NLRP3 inflammasome and its pro-inflammatory cytokines (e.g., IL-1β and tumor necrosis factor (TNF)-alpha) in patients with psoriasis [14-16], suggesting the potential of inhibiting NLRP3 and its cytokines in managing psoriasis and fatigue. The gene discussed is NLRP3; the disease is psoriasis.