The NF-κB inactivation leads to the suppression of many NF-κB-regulated genes involved in cancer development like tumor necrosis factor α (TNF-α), cyclin D1, cellular myelocytomatosis oncogene (c-myc), matrix metalloproteinases (MMP-9), cyclooxygenases (COX-2), and various other interleukins (IL-6,8) [25]. Here, NFKB1 is linked to cancer.