The cytosine-cytosine-adenosine-adenosine-thymidine (CCAAT)/enhancer-binding protein α and insulin-like growth factor binding protein-5, known suppressors of head and neck cancers, are upregulated by curcumin by activating p38 which leads to suppression of oral carcinogenesis [26]. This evidence concerns the gene IGFBP5 and head and neck cancer.