The cytosine-cytosine-adenosine-adenosine-thymidine (CCAAT)/enhancer-binding protein α and insulin-like growth factor binding protein-5, known suppressors of head and neck cancers, are upregulated by curcumin by activating p38 which leads to suppression of oral carcinogenesis [26]. The gene discussed is MAPK1; the disease is head and neck cancer.