Furthermore, to investigate whether cardiomyocyte regeneration occurs after myocardial infarction, van Berlo et al. (2014) performed direct genetic lineage tracing of c-Kit+ stem cells using c-Kit-Cre and c-Kit MerCreMer (a cardiomyocyte-specific promoter) knock-in mice to track c-Kit + stem cells during adult cardiac physiological homeostasis and after cardiac injury. The gene discussed is KIT; the disease is myocardial infarction.